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level: Drugs for Treating Bacterial Infectious Diseases

Questions and Answers List

level questions: Drugs for Treating Bacterial Infectious Diseases

Question	Answer
Inhibit bacterial cell-wall synthesis by binding to penicillin-binding proteins, inhibiting crosslinking enzymes, and activating autolytic enzymes tha disrupt bacterial cell wall that is Streptococci, meningococci, pneumococci, gram-positive bacilli, gonococci, spirochetes	Penicillins
Inhibits protein synthesis by binding, to part of the 50S ribosomal , subunit	Macrolides
Inhibits synthesis of cell-wall, mucopeptides (peptidoglycans)	Vancomycin
Inhibits peptide bond formation by binding to the 50S ribosomal subunit inhibiting peptidyl transferase	Chloramphenicol
Inhibits protein synthesis by binding to the 30S subunit of ribosomes, which blocks formation of the initiation complex, causing misreading of the code on the mRNA template and disrupting polysomes	Aminoglycosides Systemic
Inhibits protein synthesis by binding to the 30S ribosomal subunit, which interferes with binding of aminoacyl tRNA	Tetracycline
Inhibit folic acid synthesis by competitive inhibition of dihydropteroate synthase	Sulfa drugs
Inhibits folic acid synthesis by inhibition of dihydrofolate reductase	Trimethoprim
Inhibits topoisomerase II (DNA gyrase)	Fluoroquinolones
Prototype of a narrow spectrum Penicillinase-resistant that is Staphylococci	Methicillin
prototype of a narrow spectrum Penicillinase-susceptible	Penicillin G
prototype of a wide spectrum Penicillinase-susceptible that is Similar to penicillin G; also includes Penicillinase-susceptible E. coli, P. mirabilis, and H. influenzae.	ampicillin
prototype of Wide spectrum Penicillinase-susceptible that is Gram-negative rods and especially useful for Pseudomonas spp.	Carbenicillin
prototype of First-generation Cephalosporins that is Gram-positive cocci, E. coli, and K. pneumoniae	Cephalothin
prototype of 2nd-generation Cephalosporins that is Greater activity against gram-negative organisms than first-generation cephalosporins	Cefamandole
prototype of 3rd-generation Cephalosporins that is Broader activity against resistant gram negative organisms; some derivatives penetrate the blood-brain barrier	Cefoperazone
prototype of Carbapenem that is Wide action against gram-positive cocci, gram-negative rods, and some anaerobes	Imipenem
prototype of Monobactam that is Resistant to β-lactamases produced by gram-negative rods.	Aztreonam