| what is orbito-frontal cortex involved in | impulse control and response inhibition |
| What is caudate nucleus linked to | suppression of emotions/motivation/memory |
| What is the thalamus involved in | compulsive behaviour |
| worry cycle | overactive orbito-frontal cortex signals feeling of worry. Then damaged caudate nucleus fails to suppress these feelings, therefore it activates the (overactive) thalamus which induces compulsive behaviour. This compulsive behaviour then triggers the orbito-frontal cortex again, restarting the cycle |
| What is diathesis stress model | Genes cause vulnerability to OCD, but the envirionment is what triggers it |
| Candidate genes | Genes that increase a vulnerability to OCD |
| What are the two candidate genes | SERT- less seritonin
COMT- more dopamine |
| What are polygenetic genes | Multiple (up to 230) genes involved in OCD |
| What are aitologically hetrogenous genes | Origin of OCD comes from different genes. |
