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level: Level 4 - (IV. PHOTOTOXICOLOGY) continuation

Questions and Answers List

level questions: Level 4 - (IV. PHOTOTOXICOLOGY) continuation

Question	Answer
1 is a hereditary condition characterized by extreme sun sensitivity (vampire) 2 for people with this autoimmune disease, there is photosensitivity.	1 Xeroderma pigmentosum 2 Lupus erythematous
For individuals who have these __ their cells do not have the ability to repair UV light induced damage. Immediate painful blistering after exposure to the sun	Xeroderma pigmentosum and Lupus erythematous (individuals who have both conditions)
is a form of blood disorder. Porphyrin absorbs light and gets energized, eventually generating toxic free radicals	Porphyrias
Porphyrias MOA	1 enzyme abnormalities 2 disrupt the biosynthetic pathways 3 produces heme 4 accumulation of porphyrin precursors 5 fluorescence to light of 400 – 410 nm wavelength and eventually generate toxic-free radicals
Porphyrias fluorescence to light of __ wavelength and eventually generate toxic-free radicals	400 – 410 nm
referred colloquially as Vampire Disease. People with this condition often experience symptoms following exposure to sunlight. - Too much use of alcohol, estrogen, or certain antibiotics can cause photosensitivity.	Porphyria cutanea tarda
- is a type IV delayed hypersensitivity reaction that leads to eczema. There is prior sensitization to a chemical. ● Same mechanism as contact dermatitis ● Only needs low amount to elicit response	Photoallergy
Photoallergy has the same mechanism as contact dermatitis, however it requires __ to convert the potential photosensitizing chemical that will elicit the allergic response.	UV light
DIFFERENCE BETWEEN PHOTOTOXICITY AND PHOTOALLERGY	Phototoxicity - Immediate reaction. Photoallergy - A delayed response. Delayed hypersensitivity. - Gives a response at small amounts or low concentrations.