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level: Part IIA

Questions and Answers List

level questions: Part IIA

QuestionAnswer
What are transmembrane receptors with enzymatic cytosolic domain?they transduce ligand signal to activation of an enzymatic domain linked to it. they play a role in cell metabolism, growth and differentiation (EGF -epidermal), PGF...)
What are the classes of transmembrane receptors with enzymatic cytosolic domain?Receptor Tyrosine kinase (N-terminus extracellular and C cytosolic, receptors dimerize with ligand binding - becomes active kinase - activates IP3 and MAP kinase in cascade activation (GF usually)) Receptor Tyrosine phosphatase Tyrosine kinase associated receptor Receptor serine/threonine kinase Receptor guanylyl cyclase
What are intracellular receptors?For lipophilic molecules, triggering conformational change, transporting the ligand-receptor complex to nucleus, which bind to DNA sequences regulating gene expression (after it becomes dimerized)
What are extracellular receptors?Enzymes with active sites located outside the membrane, ACE for example, integral membrane protein in endothelia converting angiotensin I to angiotensin II generating active hormone AngII on vascular smooth muscle action
What are cell surface adhesion receptors?They are receptors needed for the adhesive interaction between cells in forming tissues and migration in case of inflammation. in many cases they combine to form a firm adhesion regulated by intracellular regulators by changing the affinity of their expression and localization on cell surface.