| The most common salivary gland malignancy. It showcases a spectrum of behaviors, from indolent to aggressive, making early detection crucial. Originating from reserve cells in the salivary duct system, its diverse cell composition produces both mucin and keratin | Mucoepidermoid Carcinoma |
| Recognized for its unique clinical and histomorphologic aspects. Emerging from proximal salivary duct reserve cells, it distinguishes itself with myoepithelialdifferentiated cells and a relatively indolent course compared to its counterparts. | Polymorphous Low-Grade Adenocarcinoma |
| takes center stage as a high-grade malignancy, challenging therapeutic measures with its unrelenting course. Composed of ducttype epithelial and myoepithelial cells, its fair 5-year survival rate contrasts sharply with a discouraging 15-year survival rate. | Adenoid Cystic Carcinoma |
| introduces a unique challenge with areas of clear cytoplasm, often a result of autolysis during poor fixation. Recognizing this feature becomes pivotal in accurate diagnosis | Clear Cell Carcinoma |
| prevalent in major salivary glands, may arise from intercalated duct reserve cells. While maintaining an understanding of its source is essential, there are indications that the acinic cell itself retains the potential for neoplastic transformation | Acinic Cell Carcinoma |
| Mucoepidermoid Carcinoma: MOST COMMON SITE | PAROTID GLAND |
| Represents the most common malignant tumor of salivary glands; Most common salivary gland malignancy of childhood | Mucoepidermoid Carcinoma |
| Mucoepidermoid Carcinoma:Prolonged period of painless enlargement | LOW GRADE TUMOR |
| Mucoepidermoid Carcinoma:Resembles extravasation or retention- type mucocele (w/in oral cavity) | LOW GRADE TUMOR |
| Mucoepidermoid Carcinoma:Rapid growing; Pain and mucosal ulceration | HIGH GRADE TUMOR |
| Mucoepidermoid Carcinoma:Facial nerve involvement or obstructive signs in major salivary gland; Facial nerve involvement or obstructive signs in major salivary gland | HIGH GRADE TUMOR |
| Mucoepidermoid Carcinoma: tx low grade | Surgery |
| Mucoepidermoid Carcinoma:tx high grade | Surgery and postoperative radiotherapy |
| Second most common malignant malignant salivary gland tumor accounting for 26% of all salivary carcinomas | POLYMORPHOUS LOW GRADE ADENOCARCINOMA |
| Parotid gland- Arising out of malignant transformation of a pleomorphic adenoma | POLYMORPHOUS LOW GRADE ADENOCARCINOMA |
| Firm, elevated, nonulcerated nodular swelling; Size: between 1 and 4 cm in diameter | POLYMORPHOUS LOW GRADE ADENOCARCINOMA |
| Painless mass that may have been present for a long time with slow growth rate; Associated with bleeding, discomfort, telangiectasia, ulceration occasionally | POLYMORPHOUS LOW GRADE ADENOCARCINOMA |
| POLYMORPHOUS LOW GRADE ADENOCARCINOMA: tx | Wide surgical excision |
| uncommon type of cancer that usually develops in the salivary glands or other areas of the head and neck. Sometimes it can form in other parts of the body, including your skin, breast tissue, cervix or prostate gland.; may be solid, round and hollow or they may have holes in them. | ADENOMATOID CYSTIC CARCINOMA |
| Clinical Features: Salivary gland (produces saliva) – painless lump in the mouth, face or neck; numbness in the face; weakness in facial muscles (drooping in the face); problems swallowing or opening mouth | ADENOMATOID CYSTIC CARCINOMA |
| Clinical Features: Lacrimal gland (produces tears) – bulging eye; changes in vision | ADENOMATOID CYSTIC CARCINOMA |
| Clinical Features: Larynx (voice box) and trachea (windpipe) – hoarseness; changes in speech; difficulty breathing | ADENOMATOID CYSTIC CARCINOMA |
| Clinical Features: Skin – pain; increased sensitivity; pus and/or blood discharge | ADENOMATOID CYSTIC CARCINOMA |
| ADENOMATOID CYSTIC CARCINOMA: tx | surgery, radiation therapy and chemotherapy |
| renal cortical tumor typically characterized by malignant epithelial cells with clear cytoplasm and a compact-alveolar (nested) or acinar growth pattern interspersed with intricate, arborizing vasculature. A variable proportion of cells with granular eosinophilic cytoplasm may be present. | CLEAR CELL CARCINOMA |
| This exhibit a clear cell changes that are the result of cytoplasmic accumulation of glycogen and myofilaments, respectively. | CLEAR CELL CARCINOMA |
| lowgrade tumor that occurs predominantly in the minor salivary glands (80% of cases). Most present as submucosal masses in the palate, although other sites may be affected. | CLEAR CELL CARCINOMA |
| CLEAR CELL CARCINOMA: other name | hyalinizing clear cell carcinoma |
| CLEAR CELL CARCINOMA:tx | surgery and immunotherapy |
| proposed origin of _____is thought to be the intercalated duct reserve cell. However, there is also a suggestion that the cell itself may have the capacity for neoplastic transformation. | ACINIC CELL CARCINOMA |
| Slow growing lesion smaller than 3 cm in diameter. • Rarely dedifferentiate into rapid growth, lymphovascular invasion, and regional lymph node metastasis with levels of clinical aggressiveness | ACINIC CELL CARCINOMA |
| Slow growing lesion smaller than 3 cm in diameter. • Rarely dedifferentiate into rapid growth, lymphovascular invasion, and regional lymph node metastasis with levels of clinical aggressiveness | ACINIC CELL CARCINOMA |
| ACINIC CELL CARCINOMA: tx | surgery |
| Characterized by a malignant transformation of the epithelial component of a previously benign pleomorphic adenoma. | CARCINOMA EX PLEOMORPHIC ADENOMA |
| More than 80% of cases of Carcinoma Ex-pleomorphic adenoma are seen in major glands, primarily the ____ gland | Parotid |
| irregular, lobulated, enhanced heterogeneous mass with uneven or partial uneven margins on conventional CT and MR imaging; Calcification within the neoplasm shown on CT may be regarded as a specific sign for indicating this malignancy | CARCINOMA EX PLEOMORPHIC ADENOMA |
| CARCINOMA EX PLEOMORPHIC ADENOMA: Shows malignant cells penetrating greater than 1.5mm | invasive |
| CARCINOMA EX PLEOMORPHIC ADENOMA: Shows extracapsular invasion that measures 1.5 mm or less | minimally invasice |
| CARCINOMA EX PLEOMORPHIC ADENOMA: Small malignant focus within the center of an encapsulated pleomorphic adenoma. | noninvasive |
| Invasive carcinoma ex-pleomorphic adenoma: tx | wide excision, in junction with local lymph node dissection and adjunctive radiation therapy. |
| Minimally invasive and Non-invasive ex-pleomorphic adenoma carcinoma | surgical resection and radiation |
| A rare variant of squamous cell carcinoma, characterized by spindled tumor cells that simulate a sarcoma but are epithelial in nature | CARCINOSARCOMA |
| The lesions developed with the greatest frequency on the lower lip (42%), tongue (20%) and alveolar ridge or gingiva (19%) with the remainder scattered at other sites | CARCINOSARCOMA |
| The most common presenting findings were swelling, pain and the presence of a nonhealing ulcer. | CARCINOSARCOMA |
| The initial lesion appeared either with a polypoid, exophytic or endophytic configuration. | CARCINOSARCOMA |
| CARCINOSARCOMA: tx | Surgical removal of the tumor, with or without radical neck dissection |
| A histologically benign mixed tumor that for some reason metastasizes while still retaining its bland, benign histologic appearance. | METASTASIZING MIXED TUMOR |
| Unknown cause ; Sometimes fast growing; Hard consistency; May ulcerate and invade bone; | METASTASIZING MIXED TUMOR |
| Rounded masses with well-defined "bosselated" or "polylobulated" borders | METASTASIZING MIXED TUMOR |
| METASTASIZING MIXED TUMOR: tx | Surgery; Radiation therapy; chemotherapy |
| A clear cell–containing malignancy of salivary gland (predominantly the major glands) origin characterized with a biphasic morphology | EPIMYOEPITHELIAL CARCINOMA |
| A lobular growth pattern is generally present that is composed of two cell types: abundant intercalated duct– like elements forming ducts surrounded by clear myoepithelial cell | biphasic morphology |
| It is seen in the seventh and eighth decades of life; 2:1 female predilection; Slow growing, painless; Unilateral | EPIMYOEPITHELIAL CARCINOMA |
| Radiographic appearance: Multilocular outline; Irregular lobulated or multinodular lesion with ill-defined margins | EPIMYOEPITHELIAL CARCINOMA |
| Histopathologic features: Ductal cells and clear myoepithelial cells; Duct-like or globular structures | EPIMYOEPITHELIAL CARCINOMA |
| EPIMYOEPITHELIAL CARCINOMA: tx | Surgical resection; Parotidectomy |
| rare, typically high-grade malignant epithelial neoplasm | SALIVARY DUCT CARCINOMA |
| Parotid swelling; Facial nerve dysfunction or paralysis occurs in over one-fourth of patients | SALIVARY DUCT CARCINOMA |
| High-grade variant: most aggressive types of salivary gland carcinomas | SALIVARY DUCT CARCINOMA |
| SALIVARY DUCT CARCINOMA: tx | Complete local excision with radical neck dissection |
| Considered to be the malignant counterpart of basal cell adenoma, with a histologic resemblance to ductal carcinoma of the breast | BASAL CELL ADENOCARCINOMA |
| Painless mass or swelling in the affected gland ● Ulceration or bleeding from the lesion ● 50% recur locally; 15% metastasize to lymph nodes, rarely to lungs | BASAL CELL ADENOCARCINOMA |
| BASAL CELL ADENOCARCINOMA: tx | Surgical treatment |
| etiology: metastasis of a cutaneous or mucosal squamous carcinoma ● irradiation to the major salivary glands ● obstructive sialadenitis | SQUAMOUS CELL CARCINOMA |
| Prolonged period of painless enlargement ● resembles extravasation or retention ● type mucocele (w/in oral cavity) | LOW GRADE SQUAMOUS CELL CARCINOMA |
| rapid growing ● pain and mucosal ulceration; facial nerve involvement or obstructive signs in major salivary glands; central or intraosseous within maxilla / mandible and appears radiolucent within molar and premolar | HIGH GRADE SQUAMOUS CELL CARCINOMA |
| SQUAMOUS CELL CARCINOMA: TX | resection |
