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level: Level 10 - DNA RNA

Questions and Answers List

level questions: Level 10 - DNA RNA

Question	Answer
DNA & RNA SYNTHESIS INHIBITORS	1 QUINOLONES 2 NITROFURANTOIN 3 METRONIDAZOLE 4 DAPTOMYCIN 5 RIFAMPICIN
MAINLY GRAM-NEGATIVE MOA: stimulate or increase the activity of the cutting part of the enzyme. then inhibits the ligand binding domain. so now I can't link it up together. overall results in DNA fragmentation FOR ○ GENITOURINARY TRACT INFECTIONS ○ PYELONEPHRITIS- infection of the kidneys ○ PROSTATITIS- infection of the prostate gland within males ○ OSTEOMYELITIS- caused by specific types of bacteria that lead to infections within the bone tissue.	QUINOLONES ● Ciprofloxacin ● Levofloxacin
GRAM-POSITIVE and GRAM-NEGATIVE Bacteria in through the bacterial cell and binds to the enzyme called NITROFURAN REDUCTASE. MAINLY USED FOR URINARY TRACT INFECTIONS (UTI) bactericidal.	NITROFURANTOIN
converts the nitrofurantoin into a very active metabolite, very reactive intermediate.	Nitrofuran reductase
Coverage: Gram-negative and Gram-positive used to treat: ○ H PYLORI ○ BACTERIAL VAGINOSIS- FOUL-SMELLING BACTERIA WITHIN THE VAGINA gets acted on by NITROREDUCTASE ENZYME, then it get converted into a very active metabolite. It disrupts the normal helical structure of the DNA	METRONIDAZOLE
Newer antibiotic mainly used for Gram-positive (specifically Staphylococcus aureus) ○ It FORMS A PORE INSIDE of the actual bacterial CELL MEMBRANE AND WALL; flux of ions moving in and out.; very quick and subsequent DEPOLARIZATION of the inside membrane; positive charged; INHIBIT DNA ACTIVITY	DAPTOMYCIN
used to treat: ○ TUBERCULOSIS ○ LEPROSY ○ HAEMOPHILUS INFLUENZA TYPE B MOA: Inhibits RNA POLYMERASE; It inhibits transcription of DNA to mRNA; BACTERICIDAL	Rifampicin