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level: Level 3 (LAH & SYRINGES)

Questions and Answers List

level questions: Level 3 (LAH & SYRINGES)

Question	Answer
1 Programs designed to ensure the aseptic preparation of sterile products. 2 The main elements these programs focus on are:	1 Aseptic Technique 2) 1. the development and maintenance of good aseptic technique in the PERSONNEL who prepare and administer sterile products. 2. Development and maintenance of a sterile compounding are complete with STERILIZED EQUIPMENT and SUPPLIES. 3. Development and maintenance of the SKILLS needed to properly use a LAMINAR FLOOD HOOD (LAH).
1 is a means of manipulating sterile products without contaminating them. 2 are the most important factors in preventing the contamination of sterile products.	1 Aseptic Technique 2 Proper use of a LAH and STRICT aseptic technique
should be CLEANED DAILY and SEGREGATED from normal pharmacy operations, patient specimens, nonessential equipment, and other materials that produce particles. (GIVE EXAMPLES)	Sterile Compounding Area EXAMPLES: - cardboard into the clean environment should be avoided. - traffic flow should be minimized. - floors should be disinfected periodically. - trash should be removed frequently and regularly.
1 Sterile products should be prepared in a Class __ environment, which contains no more than 100 particles per cubic foot that are 0.5 micron or larger in size. 2 are frequently used to achieve a this class environment.	1 Class 100 2) LAHs
TWICE-FILTERED LAYERS OF ASEPTIC AIR continuously sweep the work area inside the hood to prevent the entry of contaminated room air.	Laminar Airflow Hoods (LAH)
Two common types of LAH:	1 Horizontal LAH 2 Vertical LAH
Differences of HORIZONTAL and VERTICAL LAH	1 Horizontal LAH -use an ELECTRICAL BLOWER -prefilter only REMOVES gross contaminants -HIGH EFFICIENCY PARTICULATE AIR removes 99.9% OF PARTICLES THAT ARE 0.3 MICRON or larger. 2 Vertical LAH - used for ANTINEOPLASTIC - RISK OF EXPOSURE TO AIRBORNE DRUG PARTICULATES is MINIMIZED.
sweeps filtered air from the BACK of the hood to the FRONT. 1. use an ELECTRICAL BLOWER to draw contaminated room air through a prefilter. 2. The prefilter, which is similar to a furnace filter, only REMOVES GROSS CONTAMINANTS and needs to be cleaned or replaced on a regular basis. 3. The high efficiency particulate air or (HEPA) filter removes 99.9% OF PARTICLES THAT ARE 0.3 MICRON or larger.	Horizontal LAH
HEPA filtered air emerges from the top and passes downward through the work area. - used for ANTINEOPLASTIC (anticancer) drugs. - the RISK OF EXPOSURE TO AIRBORNE DRUG PARTICULATES is MINIMIZED.	Vertical LAH
removes 99.9% OF PARTICLES THAT ARE 0.3 MICRON or larger.	High Efficiency Particulate Air or (HEPA) filter
LAMINAR FLOW HOODS the type of vertical LAH used for the preparation of ANTIONEOPLASTICS contains AIRFLOW WITHIN THE HOOD and are referred to as __	. Biological Safety Cabinets (BSCs).
LAMINAR FLOW HOODS 1 The critical principle of using LAHs is that nothing interrupts the flow of air between the HEPA filter and the sterile object. The SPACE between the HEPA FILTER and the STERILE OBJECT is known as the __ 2 Materials placed within the laminar flow hood disturb the patterned flow of air blowing from the HEPA filter. This __ created behind an object could potentially extend outside the hood pulling or ALLOWING CONTAMINATED ROOM AIR into the ASEPTIC WORKING AREA. 3 It is advisable to work with objects at least __ inches from the sides and front edge of the hood without blocking air vents, so that unobstructed airflow is maintained between the HEPA filter and sterile objects.	. 1 Critical Area 2 “zone of turbulence” 3 six
LAMINAR FLOW HOODS CRITERIA 1 Nothing should be permitted to come in contact with the HEPA filter. This includes __. __ should not be opened directly toward the filter. 2 Do not put __ into the hood. 3 __ should not be worn on the hands or wrists when working in the LAH since it may introduce bacteria or particles into the clean work area. 4 Actions such as__ should be directed away from the LAH working area, and any unnecessary motion within the hood should be avoided to minimize the turbulence of air flow.	. 1 cleaning solution, aspirate from syringes, or glass from ampules, ampules 2 paper, pens, labels, or trays 3 Jewelry 4 talking and coughing
LAMINAR FLOW HOODS CRITERIA 1 __ are prohibited in the aseptic environment. 2 All aseptic manipulations should be performed at least __ inches within the hood to prevent the possibility of potential contamination caused by the closeness of the worker’s body and backwash contamination resulting from turbulent air patterns developing where LAH air meets room air. 3 LAHs should be tested by qualified personnel every __months, whenever the hood is moved, or if filter damage is suspected.	. 1 Smoking, eating or drinking 2) six 3) six
The first component of good aseptic technique is proper __ Clean garments, which are relatively particulate free, should be worn when preparing sterile products. Many facilities provide clean scrub suits or gowns for this purpose. Hair covers and shoe covers help reduce particulate or bacterial contamination, and some experts claim that the use of surgical masks and gloves is warranted as well.	Personal Attire
HANDWASHING 1 is the most common source of contamination of pharmacy prepared sterile products.	. 1 Touching sterile products while compounding
- made of either glass or plastic - most drugs are more stable in glass. - Composed of a BARREL and PLUNGER.	Syringes
Syringes 1 are most often used when medication is to be stored in the syringe for an extended period of time. 2 Many syringes have a LOCKING MECHANISM at the tip which secures the needle within a threaded ring called __	1 Glass Syringes 2 Leur-lock
Syringes 1 Available in numerous sizes ranging from __ mL. Usually the larger the syringe capacity, the larger the interval between calibration lines. 2 Ideally, the volume of solution should only take up __ of the syringe capacity. This avoids inadvertent touch contamination caused when the syringe plunger is pulled all the way back.	. 1) 0.5 to 60 (ml) 2) ½ to 2/3
The syringe package should be opened within the laminar flow hood in order to maintain sterility. The wrapper should be peeled apart and not ripped or torn. To minimize particulate contamination, do not lay discarded packaging on the LAH work surface. The syringe tip protector should be left in place until it is time to attach the needle.	.