| Are used alone or in combination and must be accompanied
by lifestyle modifications such as exercise and diet low in saturated fats. | Statins, Niacin, Fibrates, Bile
acid-binding resins, A cholesterol
absorption inhibitor and Omega-3
fatty acids |
| 7 Agents of Statins | 1. Pitavastatin
2. Rosuvastatin
3. Atorvastatin
4. Simvastatin
5. Pravastatin
6. Lovastatin
7. Fluvastatin |
| MOA OF STATINS | Competitive inhibitor of HMG
CoA reductase which is a rate
limiting step in cholesterol
synthesis and this leads to
inhibition of de novo cholesterol
synthesis and they deplete the
intracellular supply of cholesterol
then depletion of intracellular
cholesterol causes the cell to
increase the number of cell
surface LDL receptors and that
promotes the uptake of LDL from
the blood. |
| plasma
cholesterol is reduced by both
__ | 1 decreased cholesterol synthesis
2 increased LDL catabolism
ALSO
decreased
triglyceride levels and may
increased HDL cholesterol levels
in some patients |
| are the most potent
LDL cholesterol lowering state in
drug | 1 Pitavastatin
2 Rosuvastatin
3 Atorvastatin
followed by Simvastatin,
Pravastatin,
Lovastatin,
Fluvastatin |
| Reduction of elevated total and
LDL cholesterol levels to slow
progression of __ | coronary artery
disease |
| ANTIHYPERLIPIDEMIC DRUGS S/E: | 1 Elevated liver enzymes may occur, liver function
must be evaluated before starting therapy and if the
patient has symptoms
2 Myopathy and rhabdomyolysis, disintegration of skeletal
muscles have been rarely reported.
3 The seven agents may increase the effect of
warfarin and they are contraindicated during
pregnancy and lactation |
| Usually in
patients with renal
insufficiency or taking
drugs such as
erythromycin, gemfibrozil,
or niacin, __ levels
should be determined in
patients with muscle
complaints. | plasma
creatinine kinase |
