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Questions and Answers List

Question	Answer
EXOGENOUS PATHWAY 1 are formed from dietary triglycerides and cholesterol 2 ➢In adipose tissue and muscle, the enzyme __ removes the triglycerides, leaving chylomicron remnants containing intact cholesterol esters. 3 ➢When chylomicron remnants reach the liver, they are taken up by hepatocytes and then cleaved, releasing __	. 1 Chylomicrons 2 lipoprotein lipase 3 free cholesterol.
Endogenous pathways 1 __ is formed in the liver from triglycerides and cholesterol, generally as a result of high caloric intake. VLDL is released into the plasma, where lipoprotein lipase cleaves the triglycerides from VLDL 2 The hydrolysis of VLDL produces __	. 1 Very low-density lipoprotein (VLDL) 2 intermediate-density lipoprotein (IDL).
1 involved in the transport of endogenous cholesterol ester to the liver or to extrahepatic tissues. __ constitutes 60%-70% of plasma cholesterol levels. 2 is involved in the transport of cholesterol from peripheral cells back to the liver	1 LDL 2 High-density lipoprotein (HDL)
Nonspecific pathways. ➢When plasma lipoprotein concentrations are high, macrophages and other scavenger cells take part in lipoprotein degradation. ➢This leads to cholesterol deposits in __ and __	1 macrophages or arterial walls (atheromas) 2 of tendons and skin (xanthomas).
Antihyperlipidemic agents	1 HMG CoA Reductase Inhibitors 2 Bile Acid sequestrants 3 Niacin 4 Fibric Acid derivatives 5 Probucol