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Index
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ONCOLD1
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Chapter 1
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INTRODUCTION
level: INTRODUCTION
Questions and Answers List
level questions: INTRODUCTION
Question
Answer
Deals with tumors, including the origin, development, diagnosis, and treatment of benign and malignant neoplasms.
ONCOLOGY
Any injury, cells come to do their job on the site to have the process of regeneration and repair, but in terms of a sudden alteration of the process by some factors, neoplasm or cancer comes in
Oral Pathology
Encompasses of group of diseases that are marked by a rapid, uncontrolled cell proliferation and conversion of a normal cell into a more primitive and undifferentiated state.
Cancer
"NEW GROWTH"
NEOPLASMS
A new, often uncontrolled growth of abnormal tissue. (continuous process)
NEOPLASMS
Parasitic, abnormal mass of cells which grows more or less progressively unless excised or controlled by therapeutic intervention
NEOPLASMS
2 GENERAL CHARACTERISTICS OF NEOPLASMS:neoplasms compete with normal tissues and cells for their metabolic needs.
BEHAVE AS PARASITES
2 GENERAL CHARACTERISTICS OF NEOPLASMS:All neoplasms are critically dependent on an adequate blood supply derived from the host
BEHAVE AS PARASITES
2 GENERAL CHARACTERISTICS OF NEOPLASMS:It more or less steadily increases in size regardless of their local environment and the nutritional status of the host.
AUTONOMY
A diagnostic word referring to a swelling
TUMOR
Maybe due to an inflammation, a reparative process, malformation, or neoplasm
TUMOR
CLASSIFICATION ACCORDING TO BIOLOGIC BEHAVIOR:A slow growing neoplasm, remains localized, and usually does little harm to the host
BENIGN
CLASSIFICATION ACCORDING TO BIOLOGIC BEHAVIOR:A neoplasm with the ability to invade Other tissues and can cause death
MALIGNANT
Transference of disease-producing organisms or of malignant or cancerous cells to other parts of the body by way of blood or lymphatic vessels or membranous surfaces
METASTASIS
Any gene that is a causative factor in the initiation of cancerous growth
ONCOGENE
Generation of tumors
ONCOGENESIS
Capability of inducing tumor formation
ONCOGENICITY
It is an organism's ability to replace body parts,
REGENERATION
A specific method of healing that is noted for its ability to regrow lost limb, severed nerve, and other wounds,
REGENERATION
Quantitative increase in the number of cells; No significant alteration in cell structure and function
HYPERPLASIA
Cells maintain normal appearance but may have larger and slightly hyperchromatic(deeply stained) nuclei and abnormally prominent nucleoli
HYPERPLASIA
Adaptive substitution by one type of adult or fully differentiated cell; Protective or adaptive response
METAPLASIA
Main cause of metaplasia
vitamin a deficiency
FORERUNNER OF A CANCER
DYSPLASIA
Loss in the uniformity of the individual cells
DYSPLASIA
Loss of architectural orientation
DYSPLASIA
Pleomorphism (variation in size and shape)
DYSPLASIA
Deeply stained (hyperchromatic) nuclei abnormally large for the Size Of the cell
DYSPLASIA
Cells fail to develop recognizable patterns of orientation to each other
ANAPLASIA
Nuclei extremely large and hyperchromatic; variable and bizarre in size and shape
ANAPLASIA
two principal criteria by which a diagnosis of cancer is made in a primary lesion.
ANAPLASIA and evidence Of INVASION Of normal tissues
Abnormal cells that have not yet spread beyond they first formed
Carcinoma in Situ
BENIGN AND MALIGNANT(DIFFERENTIATION):Resembles tissue of origin
BENIGN
BENIGN AND MALIGNANT(DIFFERENTIATION):Less differentiated
MALIGNANT
BENIGN AND MALIGNANT(DIFFERENTIATION):Often atypical
MALIGNANT
BENIGN AND MALIGNANT(ANAPLASIA):absent
BENIGN
BENIGN AND MALIGNANT(ANAPLASIA):Present
MALIGNANT
BENIGN AND MALIGNANT(ENLARGEMENT):Usually progressive
BENIGN
BENIGN AND MALIGNANT(ENLARGEMENT):Progressive or erratic
MALIGNANT
BENIGN AND MALIGNANT(GROWTH):Slow growing
BENIGN
BENIGN AND MALIGNANT(GROWTH):Fast growing
MALIGNANT
BENIGN AND MALIGNANT(SPREAD):Expansile
BENIGN
BENIGN AND MALIGNANT(SPREAD):Localized
BENIGN
BENIGN AND MALIGNANT(SPREAD):encapsulated
BENIGN
BENIGN AND MALIGNANT(SPREAD):Invasive
MALIGNANT
BENIGN AND MALIGNANT(SPREAD):Metastatic
MALIGNANT
BENIGN AND MALIGNANT(SPREAD):unencapsulated
MALIGNANT
BENIGN AND MALIGNANT(PROGNOSIS):Amenable to surgical removal
BENIGN
BENIGN AND MALIGNANT(PROGNOSIS):Patient survival: good
BENIGN
BENIGN AND MALIGNANT(PROGNOSIS):Immediate tx needed or progressive spread follows
MALIGNANT
BENIGN AND MALIGNANT(PROGNOSIS):poor
MALIGNANT
BENIGN NEOPLASMS:Arise from fibrous tissue, composed of fibrocytes
FIBROMA
BENIGN NEOPLASMS:Cartilaginous tumor
CHONDROMA
BENIGN NEOPLASMS:Epithelial neoplasms producing gland patterns/derived from gland
ADENOMA
BENIGN NEOPLASMS:Epithelial neoplasms growing on any surface, producing finger-like warty growths or microscopic projections.
PAPILLOMA
MALIGNANT NEOPLASMS: Any stratified squamous epithelium of the body.
Squamous cell carcinoma
MALIGNANT NEOPLASMS: Lesion where neoplastic epithelial cells grown in gland patterns
Adenocarcinoma
Arise from mesenchymal tissue or derivatives
SARCOMA
arise from all 3 germ layers; epithelial
CARCINOMA
TWO BASIC COMPONENTS OF TUMORS:Proliferating neoplastic cells
PARENCHYMA
TWO BASIC COMPONENTS OF TUMORS:Largely determines biologic behavior of the tumor and is the component from which the tumor derives its name
PARENCHYMA
TWO BASIC COMPONENTS OF TUMORS:Supporting layer of connective tissue, blood vessels, and lymphatics
STROMA
TWO BASIC COMPONENTS OF TUMORS:Provides support for the growth of parenchymal cells
STROMA
TWO BASIC COMPONENTS OF TUMORS:Structural support of parenchyma and carries with it nutrient blood supply
STROMA
If there is parenchyma but stroma is absent, it causes ____ of the neoplasm
death
TWO TYPES OF STROMA:“Fleshy tumor”, very little fibrous stroma, soft and fleshy
Sarcoma
TWO TYPES OF STROMA:(less connective tissue)
Sarcoma
TWO TYPES OF STROMA:Gritty hardness due to a very strong stromal proliferative reaction
Desmoplasia
TWO TYPES OF STROMA:scirrhous” (e.g. scirrhous carcinoma of the breast)
Desmoplasia
4 PATHWAYS OF INVASION AND METASTASIS:E.g. Cancer of mucosa at wall of gut + visceral peritoneum
SEEDING OF CANCERS
4 PATHWAYS OF INVASION AND METASTASIS:Reimplants at distant sites throughout peritoneal cavity
SEEDING OF CANCERS
4 PATHWAYS OF INVASION AND METASTASIS:Peritoneal Cavities (Pleural, pericardial, subarachnoid spaces)
SEEDING OF CANCERS
4 PATHWAYS OF INVASION AND METASTASIS:Transport of tumor cell fragments by surgical instruments of Surgeon’s gloved hands to sites away from the origin of the cancer.
TRANSPLANTATION
4 PATHWAYS OF INVASION AND METASTASIS:Most common
LYMPHATIC DRAINAGE
4 PATHWAYS OF INVASION AND METASTASIS:Tends to follow the natural drainage paths of the site of tumorous invasion
LYMPHATIC DRAINAGE
4 PATHWAYS OF INVASION AND METASTASIS:E.g. Cancer of breast(oncocytes) à axillary nodes à nodes along internal mammary artery and suprainfraclavicular regions
LYMPHATIC DRAINAGE
4 PATHWAYS OF INVASION AND METASTASIS:Most important other than lymphatic (because once blood vessels are invaded, metastasis or spread of cancer can be as fast as a lightning)
BLOOD VESSEL INVASION
4 PATHWAYS OF INVASION AND METASTASIS:E.g. renal carcinoma à renal vein à inferior vena cava
BLOOD VESSEL INVASION
The term used to describe a malignant transformation wherein the entire thickness of the epithelium is involved with dysplastic changes is
Carcinoma in Situ
The following are mesenchymal in origin, EXCEPT Liposarcoma, Chondrosarcoma, Fibrosarcoma, Colonic polyp
Colonic polyp