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level: Difficult

Questions and Answers List

level questions: Difficult

Question	Answer
Hematopoeisis occurs via the stepwise maturation of ____ hematopoetic stem cells	CD34+
B-ALL is characterized by lymphoblasts that express what 3 markers?	CD10, CD19, CD20
T-ALL is characterized by lymphoblasts that express what markers?	CD2-CD8
CLL is characterized by the proliferation of naïve B cells which express what markers?	CD5 and CD20
surface marker normally expressed in T-cell and presence of this in B cells is abnormal	CD5
Reed-sternberg (RS) cells are classically positive for what markers?	CD15 and CD30
cells in hairy cell leukemia are positive for what?	tartrate-resistant acid phosphatases (TRAP)
Hairy cell leukemia shows excellent response to this drug which is an adenosine deaminase inhibitor	2-CDA (cladribine)
chromosome that codes for c-myc	chromosome 8
chromosome which encodes for Cyclin D1 gene	chromosome 11
Chromosome that codes for Ig Heavy chain which is constituatively activated	chromosome 14
chromosome which encodes for retinoic acid	chromosome 17
chromosome that codes for BCL2	chromosome 18
protein that prevents the leaking out of cytochrome c from the mitochondria	BCL2
Treatment of Follicular lymphoma which is an anti-CD20 antibody	Rituximab
promotes G1/S transition in the cell cycle	cyclin D1
chemotactic substance which attracts eosinophilis	IL-5
chemotactic substance that stimulates plasma cells growth and immunoglobulin production	IL-6
there is an increased risk of infection ni multiple myelom because monoclonal antibodies lack _______	antigenic diversity
Rouleaux formation of RBCs occurs because increased serum protein results in what?	Decreased charge between RBC