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Questions and Answers List

level questions: Moderate

Question	Answer
Lymphocytic leukocytosis resulting form EBV infection is comprised of what cells?	reactive CD8+ T cells
Definitive test for kissing disease	serologic testing to the EBV viral capsid antigen
Patients with infectious mononucleosis are generally advised contact sports for 1 year because it increases the risk for what?	Spleenic Rupture
ALL is associated with what age group?	children with Down syndrome AFTER the age of 5
Acute megakaryoblastic anemia is associated with what age group?	children with Down syndrome BEFORE the age of 5
B-ALL cytogenic abnormality with a good prognosis	t(12;21)
B-ALL cytogenic abnormality with a poor prognosis	t(9;22)
chromosomes involved in the APL	t(15;17)
chromosomes involved in CML	t (9;22) or Philadelphia Chromosome
chromosomes involved in Follicular Lymphoma	t(14;18)
chromosomes involved in Mantle cell lymphoma	t(11;14)
chromosomes involved in Burkitt's Lymphoma	t (8; 14)
Acute Myeloid Leukemia is associated with what age group?	older adults 50-60 years old
common age group which by MPD appears	late adulthood 50-60 years
Complication of MPD due to high turnover of cells	hyperuricemia and gout
BCR-ABL fusion has what kind of activity?	tyrosine kinase activity
first line treatment in CML which blocks tyrosine kinase activity	Imatinib
this stain in positive in leukemoid reaction but not in CML	leukocyte alkaline phosphatase (LAP) stain
Mutation in PV	JAK2 kinase
without treatment, death occurs in PV after how long?	one year
distinguishes PV from reactive polycythemia	decreased erythropoietin levels
Histologic lymph node changes seen in patients with rheumatoid arthritis and early stages of HIV infection	Follicular hyperplasia (B-cell region)
Histologic lymph node changes seen in patients with viral infection	Paracortex hyperplasia (T-cell region)
seen in lymph nodes that are draining a tissue with cancer	sinus histiocytes hyperplasia
overexpression of BCL 2 inhibits what?	Apoptosis
present in serum protein electrophoresis which suggests multiple myeloma	M-spike
M-spike is most commonly due to an increase in what types of Immunoglobulin	IgG or IgA
vitamin A derivative whiihc binds the altered RAR and causes the blasts to mature	all-trans-retinoic acid (ATRA)