level: Effects of NSAIDs
Questions and Answers List
level questions: Effects of NSAIDs
| Question | Answer |
|---|---|
| Anti-inflammatory Actions | COX inhibition DIMINISHES FORMATION OF PROSTAGLANDINS thus modulates aspects of inflammation |
| Analgesic Actions | DECREASE PGE2 SYNTHESIS (sensitize nerve endings to the action of bradykinin, histamine and other chemical mediators released locally by inflammatory process) |
| Antipyretic Actions | IMPEDE PGE2 SYNTHESIS AND RELEASE Fever occurs when set-point of the anterior hypothalamic thermoregulatory center is elevated caused by PGE2 synthesis, which is stimulated when endogenous pyrogens (cytokines) are release from WBC activated by infection, hypersensitivity, malignancy or inflammation |