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level: Level 3 - NSAIDS

Questions and Answers List

clinical pharmacology of non-steroidal anti-inflammatory drugs; CLASSIFICATIONS NSAIDS

Question	Answer
Outcomes of Immune Response 1 Beneficial if __ 2 Harmful if __	. 1it causes invading microbes to be PHAGOCYTOSED or neutralized 2 if it leads to CHRONIC INFLAMMATION without resolution of the underlying injurious process
• A normal, protective response to tissue injury caused by physical trauma, noxious chemicals, or microbiological agents • The body’s effort to inactivate or destroy invading organisms, remove irritants, and set the stage for tissue repair	INFLAMMATION
A chronic progressive disease causing inflammation in the joints and resulting in painful deformity and immobility, especially in the fingers, wrists, feet and ankles	RHEUMATOID ARTHRITIS
Goals in Treating Patients w/ Inflammations	•Relief of symptoms and maintenance of function •Slowing or arrest of the tissue-damaging process
The original Nonsteroidal Anti-Inflammatory Drug	Aspirin
exert antipyretic and analgesic effects	NSAIDs
Differences in safety and efficacy of NSAIDs may be explained by __ for the COX-1 and COX-2 enzyme	relative selectivity
1 responsible for PREVENTION OF Cardiovascular events and MOST ADVERSE EFFECTS 2 anti-inflammatory and analgesic actions	1 COX-1 2 COX-2
All but one of the NSAIDs are WEAK ORGANIC ACIDS as given; the exception, __ (a ketone prodrug that is metabolized to acidic active drug).	Nabumetone
Mechanism of Action of NSAIDs	Act by INHIBITING THE COX enzymes that catalyze the first step in prostanoid biosynthesis (results to DECREASED PROSTAGLANDINS)