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Index
»
QUALITY CONTROL 2 LEC
»
Compendial Requirements for Liquid Dosage Forms
»
Level 2
level: Level 2
Questions and Answers List
level questions: Level 2
Question
Answer
A LIQUID PREPARATION THAT CONTAINS ONE OR MORE SOLUBLE CHEMICAL SUBSTANCES DISSOLVED IN A SPECIFIED SOLVENT.
SOLUTIONS
CONCENTRATED SOLUTION OF A SUGAR, SUCH AS SUCROSE, IN WATER OR OTHER AQUEOUS LIQUID, SOMETIMES WITH A MEDICINAL AGENT ADDED; USUALLY USED AS A FLAVORED VEHICLE FOR DRUGS
SYRUPS
EVALUATION TESTS FOR SYRUPS
1 TRANSMITTANCE OF LIGHT 2 VISUAL INSPECTION 3 PH MEASUREMENT 4 SUCROSE CONCENTRATION 5 PHYSICAL PALATABILITY
a newer tool that is used to check syrup color. In a light transmittance meter, a syrup sample is checked for color by passing light through the sample. The percent of light transmission is compared to light transmission rates set for different grades
light transmittance meter
The ingredients and the final products are carefully examined for purity and for appearance. Physical appearance of products for patient adherence and compliance is critical so it should be GOOD LOOKING and ELEGANCE IN APPEARANCE
VISUAL INSPECTION
very important step in the quality control testing. Generally there are two different types of methods used in the measurement of pH. The pH paper which is simplest and cheapest, and for greatest accuracy is using a pH meter
PH MEASUREMENT
also very important in quality control testing of syrups. V Very high conc= crystallization, Low conc= prone to microbial growth. There is no specific method for the determination of sucrose in syrup, we use HPLC and UV spectroscopy for this purpose.
SUCCROSE CONCENTRATION
The syrups are must be stable physically. -Its appearance (no crystallization and microbial growth) -Color must be completely soluble with other ingredients -Odour and taste(palatable) -Solid material is completely miscible in liquid
PHYSICAL PALATABILITY