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level: DRUGS - 3

Questions and Answers List

Question	Answer
• derivative of nipecotic acid and was "rationally designed" as an inhibitor of GABA uptake (as opposed to the discovery through random screenings) blocks GABA reuptake in forebrain by selective blockade by GAT-1 ADJUNCTIVE TREATMENT OF PARTIAL SEIZURES	TIAGABINE Gabitril®
• a substituted monosaccharide that is STUCTURALLY DIFFERENT from all other antiseizure drugs • blocks repetitive firing of cultured spinal cord neurons, involve blocking of VG Na+ channels • potentiates inhibitory effects of GABA • depresses the excitatory action of kainate on glutamate receptors • Effective against PARTIAL AND GENERALIZED TONIC-CLONIC SEIZURES • WEST'S SYNDROME, LENNOX-GASTAUT SYNDROME, ABSENCE SEIZURES • MIGRAINE	TOPIRAMATE • Topamax®
• a sulfonamide derivative • MOA: blocks high-frequency firing via action on VG Na+ channels • Partial and generalized tonic clonic seizures • INFANTILE SPASMS AND MYOCLONIAS	ZONISAMIDE • Zonegran®
• a new triazole derivative with LITTLE SIMILARITY to other antiseizure drugs • APPROVED for use in LENNOXGASTAUT SYNDROME	RUFINAMIDE