level: Mechanism of Action
Questions and Answers List
level questions: Mechanism of Action
| Question | Answer |
|---|---|
| Atropine MOA | causes reversible (surmountable) blockade of cholinomimetic actions at muscarinic receptors |
| Ganglion-Blocking Drugs MOA | • competitively block ganglionic nicotinic receptors |
| NONDEPOLARIZING BLOCKERS MOA | At LOW DOSE: competitively block ACh at the nicotinic receptor (reversed by cholinesterase inhibitors, i.e. neostigmine) At HIGH DOSE: block the ion channels of the motor endplate |
| DEPOLARIZING AGENT MOA | Attaches to the nicotinic receptors and acts like ACh PHASE 1 & 2 |
| DEPOLARIZING AGENT MOA PHASE 1 and 2 | Phase I - causes the opening of Na channel which results to depolarization of the receptor (transient twitching of the muscle or fasciculation) Phase II – continuous depolarization gives way to gradual repolarization as the Na channel closes or is blocked (flaccid paralysis) |