level: not retained well
Questions and Answers List
level questions: not retained well
| Question | Answer |
|---|---|
| implies the ability to predict the appropriate molecular structure of a drug on the basis of information about its biologic receptor | Rational Drug Design |
| Factors Influencing Bioavailability | 1 First-pass Hepatic Metabolism 2 Solubility of the drug 3 Chemical instability 4 Nature of the drug formulation |
| • Concentration of drug at the receptor site • Commonly measured in the blood (Exception for topical agents) | EFFECTIVE DRUG CONCENTRATION |
| Metabolism (Biotransformation) May be affected by | • Drug Interactions due to inducers, inhibitors, and substrates • Genetic factors • Disease states |
| EXCRETION; Renal elimination of drugs: | – Glomerular filtration – Proximal tubular secretion – Distal tubular reabsorption |