level: CNS Depressant MOA
Questions and Answers List
level questions: CNS Depressant MOA
| Question | Answer |
|---|---|
| Benzodiazepine MOA | 1 Bind to GABA a Receptor at different allosteric sites 2 Facilitates GABA action 3 Benzodiazepine increase FREQUENCY of OPENING of the Chloride channels 4 Membrane HYPERPOLARIZATION (decrease in cell excitability) 5 CNS Depression |
| Barbiturates MOA | 1 Bind to GABA a Receptor at different allosteric sites 2 Facilitates GABA action 3 Barbiturates increase DURATION of OPENING of the Chloride channels 4 Membrane HYPERPOLARIZATION (decrease in cell excitability) 5 CNS Depression |
| Non Benzodiazepine MOA | 1 Acts on the alpha 1 subunit 2 Promote sleepiness |
| Anti-Manic Agents: Lithium salts MOA | 1 Lithium inhibits inositol monophosphatase 2 Inhibits PIP2 3 Reduced release of IP3 and DAG 4 Decreased manic episode 5 Mood stabilized |