level: Tetracycline Structure
Questions and Answers List
level questions: Tetracycline Structure
| Question | Answer |
|---|---|
| Tetracycline are 1 __ compounds, forming salts with either acids or bases 2 In neutral solutions, these substances exist mainly as __ 3 Commercially, available tetracyclines are relatively __ | . 1 Amphoteric 2 Zwitterions 3 water-soluble HCL salts |
| The unusual structural groupings in the tetracyclines produce three acidity constants in aqueous solutions of the acid salts __ | 1 pka 1 - acidic (conjugated trione system) 2 pka 2 - neutral (extending enone system) 3 pka 3 - basic (ammonium cation moeity) |
| Tetracyclines are derived from what ring system? | Octahydronaphthacene |
| are used most commonly for oral administration and usually encapsulated because they are bitter. | Hydrochloride salts |
| is obtained from bases (Na/KOH) | Water soluble salts |
| are formed with divalent and polyvalent metals | Water insoluble salts |