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Questions and Answers List

Question	Answer
Tetracyclines are obtained by fermentation procedures from __	Streptomyces spp. other way: Chemical transformation of natural products
Tetracycline Characteristics	Four Rings Bound Together Bind to A-site on 30s - Inhibits Binding to tRNA to mRNA Ribosome Complex - Shuts down Protein Synthesis
Tetracycline chemical identities have been established by degradation studies and confirmed by the synthesis of 3 members of the group __, __, __ in their alpha-forms	1 Oxytetracycline 2) 6-demethyl-6-deoxytetracycline 3) Anhydrochlortetracycline
The important members of Tetracyclines are derivatives of __, a hydrocarbon system that comprises four annulated six-membered rings	Octahydronaphthacene
The stereochemistry of the tetracyclines is very complex. Carbon atoms at __ are potentially chiral depending on substitution.	1) 4, 4a, 5, 5a, 6, and 12a
Tetracyclines with 5 alpha-hydroxyl substituent and have six asymmetric centers	1 Oxytetracycline 2 Doxycycline
Tetracycline MECHANISM OF ACTION	1 Bind to 30s subunit of the bacterial ribosome, blocking the access of the amino acyl-tRNA to the mRNA-ribosome complex at the acceptor site 2 Bacterial protein is inhibited