| concentrated aqueous preparations of a sugar or sugar substitute with or without flavoring agents and medicinal substances.
provided a pleasant means of administering a liquid form of a disagreeable-tasting drug. | Syrups |
| 1 Syrups containing flavoring agents but not
medicinal substances are called
2 Syrups are effective in the administration of drugs to __ since their pleasant taste usually dissipates any reluctance on the part of the child to take the medicine. | 1 nonmedicated or flavored vehicles
2 Youngsters |
| Medicated syrups contain: | 1 Sucrose
2 Purified water
3 Flavoring agents
4 Coloring agents
5 THERAPEUTIC AGENT <--- |
| 1 Any water-soluble drug that is stable in aqueous solution may be added to a flavored syrup. TRUE OR FALSE?
2 Care must be exercised to ensure compatibility between the drug substance and the other formulative components of the syrup. TRUE OR FALSE? | 1 TRUE
2 TRUE |
| Components of Syrups | 1 Sugar (Sucrose)
2 Antimicrobial Preservatives
3 Flavorant
4 Colorants
5 Special solvents:
alcohol,
Solubilizing agent,
thickeners,
Stabilizers |
| 1 Sucrose based syrup
2 Non-sugars syrup
3 Non Glyco genetic substances | 1 Dextrose
2 Sorbitol, Glycerin, Propylene glycol
SGP
3 Methylcellulose,
Hydroxyethylcellulose
CELLS |
| 1 Most syrups contain a high proportion of sucrose, usually __ %
2 Concentrated sugar solutions are quite resistant to __
3 Specific gravity of syrup | 1) 60-80%.
2 microbial growth
3) 1.313 |
| 1 If the solution is saturated with sucrose
2 Syrup, NF, Simple syrup ingredients | 1) It will crystallize
2) 85 g sucrose, (46.3g or mL) purified water
=100 ml syrup |
| Antimicrobial preservatives (SYRUP) | 1 Benzoic acid (0.1 to 0.2%)
2 Sodium benzoate (0.1 to 0.2%)
3 Methyl-, propyl-, and butylparabens (0.1%)
4 Alcohol (15 to 20%) |
| Syrups can be preserved by | 1 Storage at low temperature
2 Adding preservatives in the formulation
3 Maintenance of a high concentration of sucrose as a part of the formulation
SAM |
| Flavorants (SYRUP) | 1 Synthetic Flavorants
2 Naturally occurring materials
3 Volatile oils
4 Vanillin
Because syrups are aqueous preparations, these flavorants must be water soluble. |
| water soluble,
nonreactive with the other syrup components,
color stable at the pH range and under the intensity of light that the syrup is likely to encounter during its shelf life. | Colorant |
| Preparation of Syrups | 1 Solution of the ingredients with the AID OF HEAT,
2 Solution of the ingredients by agitation WITHOUT AID OF HEAT, or the simple admixture of liquid components,
3 Addition of sucrose to a prepared medicated liquid or to a flavored liquid,
4 PERCOLATION of either the source of the medicating substance or of the sucrose. |
