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level: Level 1

Questions and Answers List

level questions: Level 1

Question	Answer
1 Civilization to use suppositories 2 There is a continuous tendency not to use rectal delivery for routine administration. TRUE OR FALSE	1 Ancient Egypt 2 TRUE
1 for treatment in male erectile dysfunction 2 for post menopausal women	1 Urethral suppository 2 Progesterone vaginal inserts
Suppositories have been generally employed for three reasons	1. Promote defecation 2. Introduce drugs into the body 3. Treat anorectal diseases (like hemorrhoids)
often not first choice good alternative for oral route low cost and lack of technical difficulties compared to parenteral therapy	Rectal administration
DOWNSIDE OF Rectal administration	stigma of violating patient's dignity AND aesthetics, potential rectal irritation, difficulty in titrating correct dose
Rectal administration advantages	Essential in palliative medicine Excellent dosage forms for patients who does not want to administer numerous injections daily Administered to avoid nausea and vomiting for Paediatric and hospice patients Fast onset of action
Suppositories latin and meaning	Latin: "supponere" meaning 'to place under' sub (under) ponere (to place)
solid dosage form in which one or more APIs are dispersed in a suitable base and molded or otherwise formed into a suitable shape for insertion into the rectum to provide LOCAL OR SYSTEMIC EFFECT Solid dosage forms intended for insertion into the body orifices where it; MELT, SOFTEN, OR DISSOLVE AND EXERT LOCALIZED OR SYSTEMIC EFFECTS.	SUPPOSITORIES
solid dosage forms that is inserted into a naturally occurring (nonsurgical) body cavity other than mouth or rectum, including vagina and urethra. Tablet in appearance	Insert ex. Monistat
convenient form for administering topical drugs.	Medication sticks ex. Mentholatum (medicated lip stick) Oxy (acne medication)
Suppository, Insert and Stick shapes various shapes: __	1 Round oval 2 Long oval 3 Teardrop 4 Bullet 5 Tampon
1 Rectal Suppositories Length and Shape 2 Adult rectal suppositories Weight 3 What shape is mostly available in the market?	1) 32 mm (1.5 inches) in length Cylindrical, one or both ends tapered. Some are Bullet shaped, Torpedo or The Little Finger 2) about 2 grams when cocoa butter (theobroma oil) is used as a base. 3) Bullet Shaped
Rectal suppositories for use by infants and children are about half the weight and size of the adult suppositories and assume a more __ shape. Intended for both local and systemic actions	pencil-like 5g weight
Called pessaries or suppositories, are usually globular, oviform, or cone-shaped and weigh about 5 g when cocoa butter is the base Depending on the base and the manufacturer's product, the weights may vary widely.	Vaginal inserts
Vaginal Inserts shape	1 Globular 2 Oviform 3 Teardrop 4 Bullet 5 Tampon
called bougies, are slender, pencil-shaped suppositories intended for insertion into the male or female urethra.	Urethral suppositories
1 Male urethral suppositories Length and Weight 2 Female urethral suppositories Length and Weight	1) 140 mm long, 4 g (Cocoa Butter is employed as base) 2) 70 mm long (half), 2 g (half)