| PIPERAZINE MOA | Blocks response of ascaris muscle to acetylcholine, causing flaccid paralysis in the worm,
which is dislodge from the intestinal wall and expelled in the feces. |
| Pyrantel Pamoate MOA | Depolarizing neuromuscular blocking agent
that causes spastic paralysis in
susceptible helminths |
| Thiabendazole MOA | Inhibits helminth specific enzyme fumarate reductase,
also arrest nematode cell division in metaphase by interfering with microtubule assembly. They exhibit a
high affinity for tubulin, the precursor protein for microtubule synthesis. |
| Mebendazole MOA | Irreversibly blocks glucose uptake in susceptible helminths, thereby depleting glycogen stored in the parasite.
It also inhibits cell division in nematodes. |
| Oxamniquine MOA | inhibit DNA, RNA and protein synthesis in schistosomes |
| Praziquantel MOA | Increases cell membrane permeability of susceptible worms, resulting in the loss of extracellular calcium.
Massive contractions and ultimate paralysis of the fluke musculature occurs, followed by phagocytosis of the parasite. |
| IVERMECTIN MOA | Activates glutamate-gated Cl channels and immobilizes parasite by tonic paralysis |
| NICLOSAMIDE MOA | Inhibits oxidative phosphorylation |
| Diethylcarbamazine | Immobilize, alter surface structure of parasites
making them susceptible to destruction |
| Benzimidazoles MOA | Inhibits microtubule synthesis by binding to B-tubulin
Inhibit mitochondrial reductase
Immobilize parasites |
