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level: level 2

Questions and Answers List

level questions: level 2

Question	Answer
Parent compound from which oxyquinoline have been derived	8-hydroxyquinoline
1 The substitution of an __ at __ position of 8-hydroxyquinoline yields compounds with broad spectrum amebicidal activity	1 iodide atom, 7
treatment for acute and chronic intestinal amebiasis, not in extraintestinal High incidence of topic neuropathy Should not be used routinely in Traveller's diarrhea	Iodoquinol
Direct amebicidal action in E. histolytica Protoplasmic poison that inhibit protein synthesis in protozoan and mammalian cells by preventing protein elongation	Emetine and Dehydroemetine
1 Used in balantidial dysentery, fluke infestations (fascioliasis and paragonimiasis)	1 Dehydroemetine
1 Emetine side effects 2 Compared to emetine, HAS LOWER INCIDENCE OF CARDIOTOXICITY, CDC	1 GI Distress, Hypotension, arrythmia, Neuromuscular 2 Dehydroemetine
1 Treatment of pneumonia caused by P. carinii; Used as treatment and prophylaxis and treatment of African trypanosomiasis	1 PENTAMIDINE ISETHIONATE
PENTAMIDINE ISETHIONATE Side Effects	1 Cough, Bronchospasm, hypertension, hypoglycemia
1 Water insoluble analog of ubiquinone 6; Alternative to Trimethoprim-sulfamethoxazole Drugs Also treatment against P. carinii	1 ATOVAQUONE
1 Atovaquone Side Effects 2 Atovaquone for absorption to increase 3 Atovaquone to prevent the emergence of resistance	1 GI Intolerance 2 High fat content foods 3 Proguanil (potentiates malarial action)
Treatment of meningoencephalitic stage of west african sleeping sickness	Eflornithine
1 Eflornithine Side Effects 2 What must be monitored when taking Eflornithine?	Myelosuppressive drugs that causes 1 High incidence of anemia, Leukopenia, Thrombocytopenia 2 CBC (Complete Blood Count)
Treatment for T. Cruzi	Nifurtimox (Developed by Bayer 2502)
Nifurtimox Side Effects	Abdominal pain, Anorexia, Central and Peripheral Nervous system toxicity