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level: Level 2

Questions and Answers List

level questions: Level 2

Question	Answer
are prepared so that an initial dose of drug is released immediately followed later by a second dose. may be prepared with the immediate-release dose in the tablet’s outer shell or coating with the second dose in the tablet’s inner core, separated by a slowly permeable barrier coating.	Repeat action tablets
1 In Repeat action tablets, the drug from the inner core is exposed to body fluids and released __ after administration 2 Repeat action tablets examples 3 Repeat action tablets are best suited for treatment of __	1) 4 to 6 hours 2 Polaramine 3 Chronic conditions
IV. Delayed-release oral dosage forms The release of a drug from an oral dosage form may be intentionally delayed until it reaches the intestines for several reasons.	1 to protect a drug destroyed by gastric fluids 2 to reduce gastric distress caused by drugs particularly irritating to the stomach. 3 to facilitate GI transit for drugs which are better absorbed from the intestines.
1 Capsules and tablets specially coated to remain intact in the stomach and to yield their ingredients in the intestines are termed __ 2 The enteric coating may be: 3 Among the many agents used for enteric coating of tablets and capsules are:	1 enteric coated. 2 -pH dependent (break down in less acidic) -time dependent (erodes by moisture over time) -enzyme dependent (deteriorate by hydrolysis) 3 fats, fatty acids, waxes, shellac, and cellulose acetate phthalate.
V. USP requirements and FDA guidance for modified-release dosage forms	1) Drug release 2) Uniformity of dosage units 3) In vitro/in vivo correlations (IVIVCs) 4) Labeling
TIME AND AMOUNT DISSOLVES 1) 1 Hour 2) 2 Hours 3) 4 Hours 4) 8 Hours	1) between 15% and 40% 2) between 25% and 60% 3) between 35% and 75% 4) not less than 70%
Modified-release tablets and capsules are packaged and stored in __	the same manner as conventional products.