level: ANTI TUBERCULAR and ANTILEPROSY DRUGS MODE OF ACTION
Questions and Answers List
level questions: ANTI TUBERCULAR and ANTILEPROSY DRUGS MODE OF ACTION
| Question | Answer |
|---|---|
| 1 Isoniazid Mode of Action | 1 Inhibits synthesis of mycolic acid |
| 1 Rifampin & Rifabutin Mode of Action | 1 Binds to B subunit of DNA-dependant RNA Polymerase and inhibit it |
| 1 Ethambutol Mode of Action | 1 Inhibits Arabinosyl Transferase enzyme and prevent polymerization of arabinoglycans |
| 1 Pyrazinamide Mode of Action | 1 Activated to pyrazionic acid under acidic conditions 2 Inhibits Mycobacterial fatty acid synthase-1 Enzyme and disrupts mycolic acid synthesis 3 Binds to ribosomal proteins S1 and inhibits translation |
| 1 Antileprosy Drugs 2 Mode of Action of these drugs | 1) 1 Dapsone 2 Clofazimine 2 Dapsone: Inhibits Folic acid synthesis Clofazimine: Binds to mycobacterial DNA & Inhibit Bacterial Growth |