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Index
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PHARM DDS
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Powders and Granules.pptx
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Methods for determination of Particle size
level: Methods for determination of Particle size
Questions and Answers List
level questions: Methods for determination of Particle size
Question
Answer
Methods for determination of Particle size
1 Sieving 2 Microscopy 3 Sedimentation rate 4 Light energy diffraction or light scattering 5 Laser scattering 6 Laser holography 7 Cascade impaction Pneumonics: S M S 3L C
1 particles passed by mechanical shaking through a series of sieves known and successively smaller size and proportion of powder passing through or being withheld on each sieve is determined 2 sample particles are sized through the use of a calibrated grid background or other measuring device ( indicate range )
1 Sieving 2 Microscopy: ( range 0.2 to 100 um)
1 particle size is determined by measuring terminal settling velocity of particle through a liquid medium in a gravitational or centrifugal environment ( indicate range ) 2 reduction in light reaching the sensor as the particle dispersed in liquid or gas passing sensing zone (indicate range) 3 He-Ne laser, silicon photo diode detectors, ultrasonic probe (indicate range)
1 Sedimentation rate (0.8-300 um) 2 Light energy diffraction or light scattering (0.2-500 um) 3 Laser scattering (0.02 to 2,000 um)
1 pulsed laser is fired through an aerosolized particle spray and photographed in 3 dimension with holographic camera, particle individually imaged and size (indicate range) 2 particle driven by an air stream will hit surface in its path, provides inertia to keep in the airstream
1 Laser holography (1.4-100 um) 2 Cascade impaction