| Receptor Used as Drug Target | 1 M acetylcholine receptor
2 adrenergic receptor
3 angiotensin receptor
4 dopamine receptor
5 serotonin receptor
6 opioid receptor |
| Drugs effecting on receptors | 1 Agonist
2 Antagonist
3 Partial agonist |
| These are drugs that occupy receptors and activate them | Agonists |
| Drugs that occupy receptors but do not activate them, but they block cellular activity | Antagonists |
| It has less activation or less cellular activity | Partial Agonist |
| ACE Inhibitors block what? | Block Angiotensin I from converting into Angiotensin II |
| AT1 receptor effects | 1 Vasoconstriction
2 Sympathetic activation
3 Cell proliferation
4 Aldosterone release
5 Renal sodium resorption |
| AT2 receptor effects | 1 Vasodilation
2 Inhibition of cell growth
3 Apoptosis |
| Which receptor leads to Atherosclerosis, Hypertension? | AT1 receptor |
| Lower blood pressure and increase blood to heart | ARBs |
| Adrenergic Receptors | 1 Alpha-1
2 Alpha-2
3 Beta-1 (Heart and Kidneys)
4 Beta-2 (Lungs) |
| Alpha 2 Inhibits what? | 1 Norepinephrine release
2 Acetylcholine release
3 Insulin release |
| Types of Enzymes as Drug Target | 1 Angiotensin Converting Enzyme (ACE)
2 Cycloxygenase (COX2)
3 β-Lactamase
4 Acetylcholine Esterase |
| Drugs effecting on enzyme | Enzyme Inhibitor |
| Enzyme present in bacteria | Lactamase
- can degrade penicillin |
| ACE Inhibitor effects | 1 Dry cough
2 Increase Bradykinin |
| HMG CoA Reductase Inhibitors | 1 Pravastatin
2 Lovastatin |
| Blocks calcium access to cells | Calcium Channel Blockers,
less contractility
less conductivity to the heart |
| Drugs Affecting on Ion Channel | 1 Calcium Channel Blocker
2 Potassium Channel Blocker
3 Sodium Channel Blocker |
| They bind to two nuclear enzymes, inhibiting DNA replication | Fluoroquinolones |
| Ion Channels | 1 Calcium Ion Channel
2 Potassium Ion Channel
3 Sodium Ion Channel
4 Chloride Ion Channel |
