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level: Level 5

Questions and Answers List

Question	Answer
• PVP binding with benzoic acid and nicotine derivatives	increases phosphate buffer solutions and decreases as the temperature is raised
• Crospovidone binds with acetaminophen, benzocaine, benzoic acid, caffeine, tannic acid, and papaverine HCL due what?	dipolar character and porous structure
Polymers with nucleophilic oxygen (PEG/CMC) + Drugs (Tannic acid/ Salicylic acid / Phenols) Complexes What is the disadvantage?	• Incompatibilities in suspension, emulsion, ointments
• Complexes + container will cause what?	Drug loss
• Complexes + preservatives will cause what?	decreased preservative action
• Picric acid + strong base = ?	Salt
• Picric acid + weak base = ?	Complexes
1% ointment used for burns and abrasions	• Picric acid + Butesin
• Picric acid + Carcinogenic agents will cause what?	form complex and increase carcinogenic activity
• The molecular complex of this type is obtained by mixing alcoholic solutions of equimolar quantities of hydroquinone and benzoquinone	Quinhydrone Types
Quinhydrone Types Example and Application	• Formation of green crystals Used as electrode in PH determination
• These complexes are also called occlusion compounds in which one of the components is trapped in the open lattice or cage like crystal structure of the other	Inclusion Complex
What are the classifications of Inclusion Complex?	• Channel types • Layer types • Clathrates • Monomolecular types