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level: Level 4

Questions and Answers List

level questions: Level 4

Question	Answer
• An organic coordination compound or molecular complex consists of constituents held together by weak forces of the donor-acceptor type or by hydrogen bonds • It lacks charge transfer	Organic Molecular Complexes
• Many organic complexes are so weak that they cannot be separated from their solutions as what?	definite compounds
Organic Molecular complexes are often difficult to detect by what means?	physical or chemical means
Examples of Organic Molecular Complex	• Methyl Formate • Glycol aldehyde • Ethanol • Dimethyl Ether
Classification of organic molecular complex	• Drug and caffeine complexes • Polymer types • Picric acid types • Quinhydrone types
• Drugs such as benzocaine, procaine and tetracaine form complexes with what?	Caffeine
• A number of what drugs are known to form complexes with Caffeine?	Acidic Drugs
It is used in chewable tablet formulation	• Caffeine-gentistic acid complex
• A large molecule, or macromolecule, composed of many repeated subunits • They range from familiar synthetic plastics such as polystyrene to natural biopolymers such as DNA and proteins that are fundamental to biological structure and function	Polymer Complexes
• Polymers, both natural and synthetic, are created via polymerization of many small molecules, known as	monomers
• Many pharmaceutical additives such as polyethylene glycols (PEGs), carboxymethyl cellulose (CMC) contain what?	nucleophilic oxygen.
• Carboxyl methylcellulose (CMC) + Amphetamine = ?	poorly absorbed complex (tablet additive – drug interaction)
Examples of Polymers	Carbowaxes, Pluronics
Examples of Polymer Types	Tannic acid, salicylic acid, phenols, etc
increases phosphate buffer solutions and decreases as the temperature is raised	• PVP binding with benzoic acid and nicotine derivatives