| What is a type A ADR | Effects of medication greater than needed are dose related predictable
Variants:
E.g. digoxin toxicity, hypnotics leading to sedation, beta blockers causing bradycardia |
| Biggest cause of angiodema in A&E | ACE inhibitor angiodema |
| Warfarin adverse outcome of lack of drug monitoring | Elevated INR |
| What is INR | Indicated time for a blood clot to form normally around 1.1 if taking warfarin can be 2-3 if higher clot formation is too slow |
| Type B ADRs are | Bizare not dose realted uncommon and unrelated to pharmacology can be fatal e.g. penicillin hypersensitivty malignant hyperthermia |
| Type C ADR | Dose and time related somewhat uncommon but are the culmulative effect of drug ie. too much paracetamol in 48 hours |
| Type D ADR | Delayed reaction e.g. time related are uncommon and dose related |
| Type E ADR reactions are | As the result of end use withdrawal symptome |
| Type F | common dose related caused by drug interactions |
| What is anaphylaxis | Anaphylaxis causes a series of symptoms including rash, low pusle and shock |
