level: Bisphosphonates and other antiresorptives
Questions and Answers List
level questions: Bisphosphonates and other antiresorptives
| Question | Answer |
|---|---|
| Drugs to be aware of | Oral- alendronate, risedronate, clodronate and ibandronate |
| Most commmon bisphosphonate | Alendronate |
| What happens if osteoclasts are over supressed | Get accumulation of microdamage brittleness can occur and MRONJ can occur |
| What are BPs used for | Osteoporosis, metastatic cnacers, OI, pagets, hypercalcaemia/ primary hyperparathyroidism |
| What type of patient is likely to be on higher doses of denusomab | Cancer patients |
| MRONJ stages | 0=not exposed |
| BPs | advise of small risk of MRONJ |
| How many years of BP use does MRONJ risk increase | 5 years- warn patient of this |
| If extraction site has not healed after how long should you refer | 8 weeks |
| High risk of MRONJ- | Previous diagnosis, on systemic corticosteroids in addition to BP or 9 months plus denusoumab, anti resoptive or anti angiogenic drugs for cancer management. Or on BP for 5 years |
| What cancers make the risk worse | Multiple myeloma/ prostate cancer |
| Risk for patients taking due to osteoporosis/pagets disease MRONJ risk is | 0.1% or less |
| What can also cause MRONJ | Poorly fitting denture |