| What is clorygyline | A selective MAO-A inhibitor has dietary side effects |
| What is moclobemide | A reversible MAO-A inhibitor no dietary side affects amplifies 5HT and NA |
| Tricyclics work by | Amplyfying NA and 5HT but has chollinergic side effects |
| What is reboxetine | it is a NASRI- no antichollinergic side effects |
| What is citalopram | A SSRI- no antichollinergic side effects |
| What is venlafaxine | A combined SSRI- amplifies 5HT and NA no antichollinergic side effects |
| What is busipirone | A atypical antidepressant free of major trycyclic side effects stimultes 5HT1A receptors |
| What is mirtazapine | An atypical antidepressant works by disinhibiting NA/5HT by blocking inhibitory receptors |
| What do trycyclics do | Block the reuptake of monoamines - but also blocks the reuptake of histamine and dopamine |
| What side effects do dual 5HT and NA have | Unwanted cardiac affects due to blockade no NA |
| What causes the MAOs side effects | These enzymes nomrally break down NA and 5HT as they can no longer do this have normal side effect of increased NA whcih can cause hypertension and dietary impairment |
| When are atypicals used | When the usuals havent worked try atypical as works via a different mechanism |
| SSRI examples | Sertraline, fluxotine, citalopram, escitalpram, paroxetine, fluvoaxamine |
| Side effect of TCAs dentally relevant | Dry mouth plus poor dental health |
| Examples of antidepressants | Amitrptyline, #clomipramine#, dosulpein, iipramime, lefepramime, nortiptyline and doxepin |
| Venlafaxine and duloxetine are | SNRIs for depression anxiety causes dry mouth |
| Mirtazepine is | A antagonist at central pre synaptic alpha 2 rectors increases 5HT and NA |
| NSAIDs+ SSRIs | Increased risk of GI bleeding ok for 2-4 days but avoid in elderly and at risk |
| Codeine and SSRIs | Poor analgesia due to interaction therefore use morphine |
| Benzos- treat anxiety and alchohol withdrawal + SSRIs | Inhibit oxidation of benzos so get raised levels therefore use Lorazepam or temazepam |
| Tramadol and meperidine (strong analgesics) plus SSRIs | can cause serotonin syndrome- muscle rigidity and shakes plus diarhhoea |
| Epinephrine plus levonodefrin+ MAOIs | Ephedrine and nasal congestion may lead to hypertensive crisis |
| Adrenaline plus levonodfrin + TCAs | Sympathomimetic actions recheck vital signs after use |
