| Oseltamavir and tamiflu work via | Inhibiting neuraminidase which breaks bond allowing virus to leave the cell |
| What is aciclovir used for: | Herpes simplex I II and zoster, is a pro-drug as is phosphorylated by viruses TK which is more active than the hosts |
| Reverse transcriptase inhibitors are used for | HIV |
| Raltegravir is an | Integrase inhibitor |
| Lopinavir works by | Inhibiting HIV protease which cleaves viral protein into its two functional units |
| Regime for AIDS | 2 nucleoside RT inhibitors plus one of- non nucleoside RT inhibitors, boosted protease inhibitor, and integrase inhibitor and a chemokine recptor antagonist |
| Superficial vs systemic fungal infections | Candidiasis- candida albicans |
| Amphotericin is a | antifungal |
| Nystatin- similar mechanism as amphotericin but | Topical for candida albicans |
| Azoles work by | inhibiting synthesis of ergosterol therefore less hyphae formation |
| Superficial infections are treated with | Imidazoles- for tinea and candida topical application or oral for nail/skin infections |
| Systemic infections are treated with | Triazoles e.g. fluconazole via oral or IV enter CSF |
| Terbinafine is used for | Superficial infections especially nail can be used topically or orally works |
