level: Autonomic pharmacology
Questions and Answers List
level questions: Autonomic pharmacology
| Question | Answer |
|---|---|
| Hemicholinium- no clin. uses mechanism | Competitive inhibitor of the choline carrier |
| ChAT inhibitors used clinically | No |
| Vesamicol works by | Preventing storage of ACh (via vesicular ACh transporter) |
| Bottulin toxin prevents | Exocytosis |
| Bottulin used to treat | Salivary dlrooling |
| Neostigmine and physostigmine are- | Cholinesterase inhibitors |
| Suxamenthonium works by | Agonising nicotinic receptors over two sub parts of the receptor which desensitises the receptors cauisng paralsysis |
| What are butylcholinesterases | Non specific cholinesterases |
| Complication with suxamenthonium | Is broken down by butrycholinesterases some individuals genetically lack this systemic enzyme meaning suxamenthoniuma has a paralysising effect |
| What are galantamine and rivastigimine | Nicotinic allosteric potentiating ligands |
| Decarmethonium is selective for | Nicotinic skeletal muscle |
| Antimuscarinics work via | Inhibition of parasympathetic nervous system |
| Are drugs specific to muscarinic subtypes used | No |
| What is ipratropium used for | Asthma |
| What is atropine used to treat | bradycardia |
| Pirenzepine is used to | decrease gut motility and secretions |
| Why is atropine given presurgery | Decreases secretions therefore decreasing AChEI side effects |
| What is tropicamide used for | Pupil dilation |
| Oxybutynin is used for | Urinary incontinence |
| What is hyoscine used for | motion sickness |