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level: Inflammatory drugs

Questions and Answers List

Question	Answer
Dexamethasone and betamethasone have a longer half life due to what	Fluoride
What does the double bond in the corticosteroids do	Increases the drug potency
When are cortisol levels higher	Morning
How long anti-inflammatory drugs take affect via transactivation and transrepression pathway	6-8 hours
an adrenal-cortex hormone (trade names Hydrocortone or Cortef) that is active in carbohydrate and protein metabolism	Hydrocortisone and cortisone
Intermediate acting- 12-36 hours glucocorticoids are?	Prednisolone
Long acting >36 hours glucocorticoids are	Dexamethasone
Glucocorticoid uses outside of dentistry	Allergies- (Allergic rhinitis) and (Dermatitis/eczema)
Uses of glucocorticoids in dentistry	Oral ulceration- denture induced trauma (not used for hepetic ulcers)
Chronic glucocorticoid use is similar to	Cushing's disease
Rapid stopping of glucocorticoids can lead to	Addisons disease
RISKS with chronic GC	Infection risk
Anti immunomodulators examples--	MAb- adalimumab and cetrolizumab
Paraneoplastic syndrome can cause	Cushings- lungs produce ACTH like compound
Define cachexia	TNF produced causes fat mobilisaiton and loss of apetite
Where does leukemia originate	Bone marrow red blood cells
Where does lymphoma originate	Lymphocytes