How are antibody depedent cell mediated cytotoxicity TIIHS?

➢ Low concentrations of IgM, IgG or IgE (in the case of parasites) coat target cells. Cells exhibiting the foreign antigen are tagged with antibodies (IgG or IgM). These tagged cells are then recognised by natural killer (NK) cells and macrophages (via the Fc region). Neutrophils and eosinophils may also participate in ADCC. ➢ Inflammatory cells such as NK (natural killer) cells, monocytes/macrophage, and granulocytes with Fc receptors on its surface are able to recognize and kill a target cell coated with antibody. ➢ They can lyse, but do not phagocytize the target cells, by elaboration of proteases. ➢ The constant portion of the antibody (Fc region) is bound by Fc receptors on the NK cell, leading to perforin release and NK cell–mediated lysis